科研团队
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Efremov, Artem
特聘研究员
研究方向
Study of molecular mechanisms responsible for mechanotransduction in living cells.Understanding the role of mechanical and topological constraints in regulation of DNA-protein interactions and chromatin organization in living cells.Exploration of molecular mechanisms underlying mechanochemical coupling in cytoskeletal motor proteins, and their role in regulation of intracellular transportation.Development and application of single-molecule force-spectroscopy methods for investigation of the above questions.
系统与物理生物学研究所
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Goh, W.S. Sho
特聘研究员
研究方向
主要研究方向包括:1.研发应用于重要表观转录修饰的高分辨率测序技术;2.识别新型表观转录因子,并从作用机理上阐释它们如何调控基因表达,介导细胞进程以及对人体疾病发生所起到的影响。
分子生理学研究所
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Hill, Jeffrey
转化医学中心副主任
研究方向
I firmly believe that to be successful in drug discovery one must utilize cutting edge technologies, explore the full range of drug modalities and attempt to drug the most challenging targets. I am interested in pursuing targets from all therapeutic areas especially oncology and infectious disease.
转化创新中心
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Lee, Andrew
特聘研究员
研究方向
肿瘤研究所
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Lobie, Peter E
资深研究员
研究方向
The overarching aim of his laboratory is to characterize the biology of, and develop methods of inhibition to novel and clinically relevant proteins involved in the pathophysiology of breast and other functionally related cancers. They are focused to develop proof of principle inhibitory strategies to demonstrate the potential utility of these targets in oncology and generate novel therapeutic agents for eventual clinical use. Hence, evaluation of individual molecules for their potential therapeutic application and commercial exploitation also forms an important component of the work.
医药健康技术与工程研究所
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Tan, Justin L.
特聘研究员
研究方向
The Tan lab focuses on drugging cell fate, where advanced chemical biology methods are developed and applied to identify natural product and synthetic chemical probes targeting a class of oncogenes called lineage transcription factors.
肿瘤研究所
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Yamamoto, Nobuhiko
资深研究员
研究方向
Our lab investigates the regulatory mechanisms of neuronal activity-dependent gene expression, which are involved in neuronal circuit formation and remodeling, from the physiological, pathological and evolutional points of view, using in vitro and in vivo imaging, gene expression analyses, and cellular biological techniques such as our original slice culture method.
神经疾病研究所
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蔡羽轩
特聘研究员
研究方向
致力于化学和生物医学交叉研究,通过开发新方法和新技术来解决生命科学领域的重要难题,为疾病诊断和治疗提供新工具和新思路。课题组具备化学生物学、化学合成、药物开发、基因编辑、基因密码子扩展技术等专长,专注于蛋白质功能调控,并应用于癌症等疾病的诊断和治疗,特别是生物制剂和细胞疗法的相关应用。
分子生理学研究所
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陈美欣
特聘研究员
研究方向
发掘预防与治疗传染性疾病的生物靶点。课题组主要探讨机体内病原微生物的致病机理;探讨宿主免疫系统、细胞代谢防御病原微生物的分子机理。包括:1.病原微生物的致病机理;2.机体抵抗病原微生物感染的分子机理;3.新抗菌分子的筛选和鉴定。课题组学术氛围浓厚,成员和谐友爱,共同进步,欢迎对感染、免疫、代谢等研究内容感兴趣的同学或研究人员加入我们课题组。
传染病研究所
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陈南鹏
特聘研究员
研究方向
我们致力于研究细胞在分裂,黏附和迁移中的行为及其分子机制,尤其关注细胞在增殖和癌变过程中所伴随的细胞黏附/迁移结构的巨大变化。实验室综合运用最前沿的显微技术,多组学和基因编辑技术,探索这些分子机制在三维环境和疾病进程中的生物学意义。
系统与物理生物学研究所